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Technical Software Program Manager
Grail
IT, Operations
Menlo Park, CA, USA
USD 117k-144k / year + Equity
Posted on Nov 21, 2025
Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.
We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.
GRAIL is headquartered in Menlo Park, California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.
For more information, please visit grail.com.
The Technical Software Program Manager (TPM) supports the planning, coordination, and delivery of technology-driven programs and projects across GRAIL’s Software, IT, and Platform Engineering organizations. This role combines program management discipline with technical understanding to ensure programs are executed efficiently, meet defined objectives, and align with business and technical priorities.
Operating under general direction, the TPM manages projects of moderate scope and complexity, coordinating multiple stakeholders and dependencies to ensure progress, mitigate risks, and deliver outcomes on time and within scope. The TPM applies PMBOK principles and Agile practices to maintain visibility, accountability, and alignment across cross-functional teams.
This is a hybrid role with 2-3 days in office in Menlo Park, CA. Please note we will be relocating our office to Sunnyvale, CA in 2026 and you must be willing to work a hybrid schedule from that location as well once we move.
Responsibilities
- Program Planning & Execution
- Develop and maintain detailed project plans, schedules, and deliverables across multiple workstreams of moderate complexity.
- Define scope, success metrics, and milestones in partnership with engineering, product, and operations teams.
- Track progress against key milestones, escalating risks or deviations in scope, schedule, or budget to leadership as needed.
- Cross-Functional Coordination
- Partner with cross-functional teams—including Software Engineering, Product Management, IT, and Security—to ensure alignment on priorities and dependencies.
- Facilitate team meetings and drive action items to resolution, ensuring accountability across roles and owners.
- Build strong working relationships across teams to streamline execution and resolve cross-functional challenges.
- Risk & Issue Management
- Identify risks early, propose mitigation strategies, and track resolution through completion.
- Ensure issues are escalated appropriately, fostering transparency and proactive problem-solving.
- Stakeholder Communication
- Serve as the primary contact for project updates and program status, preparing concise reports for leadership and stakeholders.
- Provide clear visibility into progress, scope changes, and delivery timelines.
- Process Improvement & Governance
- Apply program management best practices (PMBOK, Agile, or hybrid models) to improve delivery efficiency.
- Contribute to the continuous improvement of team workflows, documentation, and communication processes.
- Help define and implement program management tools, templates, and reporting standards.
- Metrics & Reporting
- Define and track KPIs (schedule adherence, risk closure rate, velocity) to measure project health and delivery success.
- Compile post-project reviews to capture lessons learned and process improvement opportunities.
- Core Competencies
- Applies professional program management expertise to resolve moderately complex issues using discretion and sound judgment.
- Exercises ownership over timelines, scope, and deliverables while following established policies and governance frameworks.
- Communicates effectively across technical and non-technical audiences, building collaborative relationships to drive progress.
- Demonstrates analytical and organizational skills to balance multiple projects and competing priorities.
- Contributes to analysis and process optimization through data-driven insight and continuous improvement mindset.
Preferred Qualifications
- Education: Bachelor’s degree in Engineering, Computer Science, Information Technology, or related field.
- PMP or other Program Management certification highly preferred (or in progress).
- 2–5 years of experience managing cross-functional, technical projects within software, infrastructure, or related technology environments.
- Demonstrated experience coordinating multiple teams and workstreams, using structured methodologies (PMBOK, Agile).
- Experience with standard program management tools (Jira, Confluence, Smartsheet, Asana, or similar).
- Familiarity with SDLC, DevOps, and cloud technologies (AWS, GCP, Azure) preferred.
Expected full time annual base pay scale for this position is $117K-$144K. Actual base pay will consider skills, experience and location.
Based on the role, colleagues may be eligible to participate in an annual bonus plan tied to company and individual performance, or an incentive plan. We also offer a long-term incentive plan to align company and colleague success over time.
In addition, GRAIL offers a progressive benefit package, including flexible time-off, a 401k with a company match, and alongside our medical, dental, vision plans, carefully selected mindfulness offerings.
GRAIL is an Equal Employment Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status. We will reasonably accommodate all individuals with disabilities so that they can participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us at RC@grailbio.com to request accommodation. GRAIL maintains a drug-free workplace.