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Operations Engineer 2, MSAT # 4411
Grail
Operations
Durham, NC, USA
USD 82k-100k / year + Equity
Posted on Nov 14, 2025
Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.
We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.
GRAIL is headquartered in Menlo Park, California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.
For more information, please visit grail.com.
GRAIL is seeking an Operations Engineer 2 for the Manufacturing Sciences and Technology team. As an Operations Engineer 2, you will provide support for Manufacturing and Lab Operations activities. Responsibilities will include the installation, maintenance, and sustained performance of cutting-edge laboratory equipment along with documenting activities in accordance with regulatory compliance guidelines. Laboratory equipment supported will range widely, but will include next-generation sequencing platforms and automated liquid handling robots. Strong interpersonal, organizational, and troubleshooting skills are essential for success in this position.
This is a full time, onsite position working in the Research Triangle Park, NC lab.
This is a first shift position, Monday to Friday starting at 8:00AM.
Work on holidays may be required.
On-call work may be required.
Working hours may be temporarily adjusted due to training, travel, and other events.
Responsibilities:
- Lead and perform live troubleshooting, recovery, debugging, repairs, and maintain equipment and systems in good working order to support the area and operators’ day to day following cGMP/GLP and Quality Management System (QMS) guidelines in a timely manner
- Make time sensitive technical decisions; collaborate and escalate when appropriate
- Ensure day-to-day reliability and maintainability of equipment, processes, mechanical, electrical, control, and safety/security systems following cGMP/GLP and Quality Management System (eQMS) guidelines
- Reduce and improve unplanned maintenance events wherever feasible, ensuring efficient and
- productive operation of equipment
- Execute and document equipment lifecycle related activities (installations, maintenance, calibration,
- repairs, etc) by supporting and maintaining equipment records in and out of our Asset Management
- System for traceability purposes and to assure compliance with CLIA/CAP, FDA 21 CFR part 820, and
- ISO 13485 requirements
- Maintain Asset Management System(s) to support internal Equipment Program processes and
- procedures
- Execute procedures, work instructions, guidelines, and testing documents such as installation /
- operational / performance qualification (IOPQ), site acceptance test (SAT), verifications, standard
- operating procedures (SOP)
- Serve as a primary point of contact for hosting vendor IQ, OQ, calibration, PM, and/or repairs with
- minimal supervision
- Ensure that all work performed by external contractors is completed and documented in accordance with
- the site Quality Management System (QMS) and safety guidelines
- Work closely with quality and regulatory to determine, include, implement and follow the required
- policies, requirements, and procedures for equipment lifecycle events
- Author and lead DAR implementations where needed; may lead equipment and equipment integration-
- related Change Controls for qualified assets
- Respond to environmental monitoring system alert notifications for areas of responsibility
Preferred Qualifications:
- BS/BA or equivalent in Engineering, Physics, Chemistry or Life Sciences with 2+ years of experience
- working on laboratory equipment or in an equivalent program
- AS or applicable certification with 5+ years of experience working on laboratory equipment or equivalent
- program
- 1+ years Hands-on experience maintaining and supporting general molecular laboratory equipment
- (hardware and software systems) and following appropriate safety procedures
- 1+ years experience technically troubleshooting and maintaining liquid handling equipment and software
- components (e.g., Agilent, Hamilton, Labcyte, Illumina etc.)
- 1+ years experience working in a regulated laboratory environment
- 1+ years experience working with IT networking and systems infrastructure
- 1+ years experience working within a computerized maintenance/calibration management system
- Excellent communication skills to serve as a point of contact for internal customer support
- Excellent time management skills to support a fast paced working environment
- Ability to travel up to 10% of the time
Physical Demands and Working Environment:
- Regularly required to stand, sit, walk, climb stairs/ladders, kneel, crouch, and wear safety gear
- Occasionally work with dry ice or materials stored at very low temperatures
- Must be able to stand or sit for long periods of time
- May be exposed to hazardous materials, blood specimens and equipment with moving parts, heating or
- freezing elements, and high speed centrifugation
- Working on confined spaces may be necessary
- Must regularly lift and / or move up to 10 pounds
- Must frequently lift and/or move up to 25 pounds
- Must occasionally lift and/or move up to 50 pounds
The expected, full-time, annual base pay scale for this position is $82K - $100K for Durham, NC. Actual base pay will consider skills, experience, and location.
Based on the role, colleagues may be eligible to participate in an annual bonus plan tied to company and individual performance, or an incentive plan. We also offer a long-term incentive plan to align company and colleague success over time.
In addition, GRAIL offers a competitive benefit package, including flexible time-off, a 401(k) with a company % match, medical, dental, and vision insurance plans, and carefully selected mindfulness offerings, in accordance with our applicable plans and policies. Learn more about our benefits here: px.sequoia.com/grail
GRAIL is an equal employment opportunity employer, and we are committed to building a workplace where every individual can thrive, contribute, and grow. It is GRAIL policy to provide equal employment opportunities without regard to race, color, religion, national origin, sex, gender, gender identity, sexual orientation, age, marital status, protected veteran status, disability status, medical condition, or any other class or characteristic protected by applicable federal, state, and local laws.
This policy applies to all phases of employment, including, but not limited to: recruiting, hiring, training, promotion, and termination at all levels of employment. GRAIL maintains a drug-free workplace.
Additionally, GRAIL will consider all qualified job-seekers with criminal histories in a manner consistent with applicable law and provide reasonable accommodations to qualified individuals with disabilities so that they can participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us at rc@grailbio.com if you require an accommodation to apply for an open position.
For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster.
We welcome job-seekers from all backgrounds to join us!